From an amateur club to a professional club : the development of the FC Würzburger Kickers

In vorliegender Arbeit wird zum einen im theoretischen Teil der Unterschied in der Struktur eines Amateurvereins und eines Profivereins aufgezeigt. Zum anderen setzt sich der empirische Teil intensiv mit dem Erfolg des FC Würzburger Kickers auseinander. Das ambitionierte “3x3-Projekt” wird tiefgreifend analysiert. Die konkreten Maßnahmen dieses Vorhabens werden dabei genauer beschrieben. Darauf bezogen wird eine empirische Studie durchgeführt. Durch die Zusammenführung dieser Schritte werden Handlungsempfehlungen gegeben, wie der Verein sich noch optimieren kann

Transcriptome-wide association study of breast cancer risk by estrogen-receptor status

Previous transcriptome-wide association studies (TWAS) have identified breast cancer risk genes by integrating data from expression quantitative loci and genome-wide association studies (GWAS), but analyses of breast cancer subtype-specific associations have been limited. In this study, we conducted a TWAS using gene expression data from GTEx and summary statistics from the hitherto largest GWAS meta-analysis conducted for breast cancer overall, and by estrogen receptor subtypes (ER+ and ER-). We further compared associations with ER+ and ER- subtypes, using a case-only TWAS approach. We also conducted multigene conditional analyses in regions with multiple TWAS associations. Two genes, STXBP4 and HIST2H2BA, were specifically associated with ER+ but not with ER- breast cancer. We further identified 30 TWAS-significant genes associated with overall breast cancer risk, including four that were not identified in previous studies. Conditional analyses identified single independent breast-cancer gene in three of six regions harboring multiple TWAS-significant genes. Our study provides new information on breast cancer genetics and biology, particularly about genomic differences between ER+ and ER- breast cancer.Peer reviewe

Build and Execution Environment (BEE): An Encapsulated Environment Enabling HPC Applications Running Everywhere

Variations in High Performance Computing (HPC) system software configurations mean that applications are typically configured and built for specific HPC environments. Building applications can require a significant investment of time and effort for application users and requires application users to have additional technical knowledge. Linux container technologies such as Docker and Charliecloud bring great benefits to the application development, build and deployment processes. While cloud platforms already widely support containers, HPC systems still have non-uniform support of container technologies. In this work, we propose a unified runtime framework - Build and Execution Environment (BEE) across both HPC and cloud platforms that allows users to run their containerized HPC applications across all supported platforms without modification. We design four BEE backends for four different classes of HPC or cloud platform so that together they cover the majority of mainstream computing platforms for HPC users. Evaluations show that BEE provides an easy-to-use unified user interface, execution environment, and comparable performance

BeeFlow: A Workflow Management System for in Situ Processing Across HPC and Cloud Systems

In this paper, we propose BeeFlow - an in situ analysis enabled workflow management system across multiple platforms using Docker containers. BeeFlow can support both traditional workflows as well as workflows with in situ analysis. BeeFlow leverages Docker containers to provide a portable, flexible, and reproducible workflow management system across HPC and cloud platforms. We showcase how current in situ visualization workflows can apply BeeFlow with DOE production codes VPIC and Flecsale